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claredesplats

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In this reporting period, the risk of progression to the different states of diabetic retinopathy (R0, R1, R2 and R3) was estimated based on data collected from patients attending systematic retinal screening in the region of East Anglia. There was a total of 14,348 patients who were followed up for a time period of 6 […]

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This reporting period was mostly about collaborations. I was able to work with many of the other ESRs and co-author a few conference papers with them. It also gave me the opportunity to collect some data from the University of Dundee to help create a new tortuosity testing dataset. Once available, the dataset will allow […]

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During this period of research, the following was achieved: Finalization of experiment protocol on adaptive remodelling of microvascular networks in CAM after acute microocclusion in arterioles and venules. In collaboration with ESR 2.4, Febro Guimaraes: Semi-automatic velocity measurement software tested. In collatoraction with ESR 2.1, Francesco Caliva, and Dr Bashir Al-Diri: Preliminary test on network […]

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During this research period, Carlos improved his retinal image registration method, which aligns retinal images. This is useful for studying the evolution of disease across examinations, or to enable other techniques such as the creation of super resolution images to perform more accurate measurements or study fluid dynamics on the retinal vessels when the images […]

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During this reporting period, the model of the retinal vascular network was improved and myogenic response gradient through the network was implemented. Major results for a modelling paper were obtained. A draft of paper on modelling was written. Also, animal experiments were carried out: set-up and methods were improved. Experiments focused on retinal reaction on […]

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These six months were mainly dedicated to the dissemination of my work: in fact, we have submitted two publications and I presented the results in two different conferences: USNCCM about computational mechanics and CMBE more related to bioengineering. At the same time we have continued working on the reduced order modeling techniques to be used […]

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The existing lesion-detection algorithm was improved with the introduction of a new template-detection method. The resulting hybrid algorithm showed higher sensitivity than the previous one. A new method for the quick detection of the optic disk was developed. A new method for the fully automatic detection of 5 clinically relevant regions was developed.

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During this reporting period, the development of a tool usable to connect flood vessels in fundus images gave a contribution to the retinal community. This work, which was published at IEEE EMBC 2015, presented a tool that used implicit neural cost functions to join retinal vessels. Results obtained showed that the quality of the segmentation […]

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The fully automated framework for curvilinear structure tortuosity quantification has been completed and tested extensively. It consists of the combination of a new ridge detector designed and developed for detecting tortuous structures (SCIRD) and learned context filters. Qualitative (the image attached shows a comparison of our curvilinear structur detector, SCIRD and state-of-the-art methods) and quantitative […]

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Microglia play a major role in retinal neovascularization and degeneration and are thus potential targets for therapeutic intervention. In vivo assessment of microglia behaviour in disease models can provide important information to understand patho-mechanisms and develop therapeutic strategies. Although scanning laser ophthalmoscope (SLO) permits the monitoring of microglia in transgenic mice with microglia-specific GFP expression, […]

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During this period, I focused mainly on extracting as many features as possible from the available DR images based on strict quality criteria (regarding inclusion of observations, power estimations and avoidance of statistical errors). Moreover, a suitable hybrid mixed model was introduced specific for the nature of my analysis which can be used when the […]

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