Weiwei Xiang – Progress Report 1

My REVAMMAD project concerns developing analytical models for simulation of blood flow and vascular structural adaptation in retinal microcirculation under physiological and pathophysiological conditions based on anatomical data from the segmentation of imaging data. In order to gain comprehensive insight into relevant mechanisms underlying function of retinal microvascular network, some other tissues in addition to retina will also be employed for biological experiments. Those extra tissues are expected to supply an easier and comprehensive way for this research because some experimental methods cannot be applied to retina.Significant research during this reporting period:1. Comprehensive theoretical knowledge gained: Insight into morphology, topology, hemodynamics and structural adaptation of microvascular networks which lays theoretical foundation for practical modelling work;2. Hands-on modelling practice in progress: Learning of Delphi programming and apprehension of in-house modelling software on structural adaptation of microvascular network;3. Biological experiments started: Starting to establish the microvascular network occlusion model on CAM.