During reporting period, model of the retinal vascular network was improved, network structure was changed fundamentally and made more realistic, mechanical properties of vessel wall were added, as well as autoregulation of vessel diameter. Program for 3D visualization of network structure and dynamics was written. In addition to modeling part of my work, were carried out preparing for animal experiments. I finished course “Laboratory Animal Science – FELASA category C”, that allow me to carry out the experiments on the laboratory animals. To get the rat retinal images we using Laser Speckle Contrast method, that is “full-field” and non invasive technique. Laser Speckle Imaging setup was build. Now, we are ready to obtain retinal images, made some tests, that we will use for improving of the model.