Weiwei Xiang – Progress Report 5

Over the past six months, I have finished data collection from my experiment on early adaptation of arteriolar collaterals in chick chorioallantoic membrane (CAM) which will be presented in my paper that is to be submitted later this month. In general, our work shows that after occlusion, unidirectional flow towards the occlusion site was established. Diameters exhibited a significant immediate decrease, followed by an increase with a time constant of 2.5 ± 0.8h (mean ± SD, P<0.05) leading to a plateau up to 60% above the baseline value without significant vascular tone change. In contrast, WSS exhibited a significant increase immediately post-occlusion, followed by an approximately linear decrease returning to the baseline value after about 12h. Maximal increase in WSS and sustained diameter changes were significantly correlated (see figures below).