A novel method for digital curvature estimation has been proposed during this period. A paper has been written and it will be submitted shortly to a journal. This particular area has been investigated since I am working on corneal nerves tortuosity, in collaboration with Harvard Medical School.The problem is to assess image tortuosity and curvature seems to be a good feature for describing tortuosity, even though they are different things. After reviewing the state-of-the-art on digital curvature estimation, I proposed a new solution to unsolved problems in this field: poor accuracy and window size selection.With our multiple-window approach we are now able to estimate digital curvature regardless of the corneal nerve’s size with high accuracy, according to huge amount of experiments on synthetic (ground truth) data.