A software tool was created for the manual supervision of lesions resulting from the automatic algorithm. The manually supervised detection of microaneurysms in the prospective database was concluded. The new method for the quick detection of the optic disk was improved, completed with an approximate segmentation and optimised for speed and accuracy. The method for the fully automatic detection of 5 clinically relevant regions was integrated with the new, fast algorithm for the optic disk detection. A new study showed that the distribution of microaneurysms in high-risk patients was higher in the upper than in the lower hemiretina (see Figure: Cumulative distribution of microaneurysms in the left and right eye).